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Bluetools project
Bluetools project
  • The project
    • About bluetools
    • How it works
    • Expected results
    • Who we are
  • Key concepts
  • Resources
    • Communication materials
    • Scientific publications
    • Conference contributions
    • Deliverables and milestones
  • News & Events
  • Contact

Publication

Microfluidics reveals new strategy for disrupting bacterial communication

24 June 2026

Bluetools researchers have developed a new ultrahigh throughput screening method to find genes that interfere with bacterial communication. The study identifies a previously unknown mechanism from one of Earth’s most …

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Categories Publication Tags bacterial communication, Blue Bioeconomy, microbiome, Microfluidics

New database makes enzyme knowledge accessible to researchers worldwide

18 June 2026

A new open-access database is helping scientists unlock the secrets of how microorganisms produce complex molecules with powerful biological properties. Bluetools researchers have contributed to the development of MITE — …

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Categories Publication Tags enzyme database, microorganism, MITE, open-access
Phylogenetic analysis and structural features of HulaChrimson

From lake microbes to light controlled technologies: discovering HulaChrimson

27 May 2026

Freshwater ecosystems continue to reveal unexpected biological diversity and hidden molecular tools. Researchers have now identified HulaChrimson, a newly discovered channelrhodopsin found through freshwater metatranscriptomic sampling in Lake Hula, Israel. …

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Categories Publication Tags HulaChrimson, lake microbes, new research, protein

Simplifying how metagenomics data is shared

21 May 2026

Sharing metagenomics data is essential for reproducibility and large-scale analysis. Yet the process is often complex and time consuming. Researchers have developed subMG, a tool that streamlines submission of metagenomics …

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Categories Publication Tags Blue Bioeconomy, data management, metagenomics data

Coral resilience depends on a fragile microbial balance

12 May 202612 May 2026

Coral health relies on a delicate balance of microbial life. New research shows how this balance shifts under stress and how it can affect coral survival. Scientists studied the microbiome …

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Categories Publication Tags coral health, coral resilience, microorganismen

New light on microbial photoreceptors from lake microbiomes

12 May 202623 April 2026

Researchers have identified a new light sensitive protein that could expand our understanding of optogenetics. The study focuses on a novel channelrhodopsin discovered in a lake microbiome. These proteins act …

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Categories Publication Tags microbial photoreceptors, microbiome, protein

Expanding the global resource for natural product discovery

12 May 202622 April 2026

A major update to a key scientific database will boost research on natural products. Researchers have released version 4.0 of the MIBiG database. It collects data on biosynthetic gene clusters, …

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Categories Publication Tags biosynthetic gene cluster, database, marine microbes, metabolites

From molecules to microbiomes: new insight into bacterial control systems

12 May 202615 April 2026

A new study from the Bluetools project sheds light on how bacteria control key survival strategies. The research focuses on a specific modification in transfer RNA, known as queuosine. This …

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Categories Publication Tags bacterial control system, microbiome, queuosine

Fluorogenic Monitoring Unlocks Ultrahigh-Throughput Enzyme Evolution

12 May 20262 April 2026

We are pleased to highlight the publication Fluorogenic, Subsingle-Turnover Monitoring of Enzymatic Reactions Involving NAD(P)H Provides a Generalised Platform for Directed Ultrahigh-Throughput Evolution of Biocatalysts in Microdroplets. This work supports …

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Categories Publication Tags enzyme, fluorogenic monitoring, NAD(P)H
Schematic overview of the study. The plasmid library was constructed by cloning a 200-nucleotide random sequence upstream of the thermostable reporter gene, superfolder citrine fluorescent protein (IFP). Plasmid DNA library was pooled from E. coli and transformed to T. thermophilus. Approximately 1500 T. thermophilus clones, arrayed on 96-well plates, were screened under UV light, and 53 fluorescent clones were selected for further characterization. The thermostable enzymes were transcriptionally fused to the IFP CDS. Plasmid DNAs were subsequently transformed into E. coli for comparative expression analysis.

Expanding the genetic toolbox for thermostable protein production

12 May 202625 March 2026

A new Open Access publication in Synthetic Biology journal presents an important step forward in enabling efficient protein production in the thermophilic bacterium Thermus thermophilus. The study addresses current limitations …

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Categories Publication Tags genetic toolbox, protein production, Thermus thermophilus synthetic biology
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This project has received funding from Horizon Europe under grant agreement No 101081957

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